Rabbit polyclonal RAMP3 antibody (A6715)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RAMP3 antibody (A6715)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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Calcitonin receptor like receptor activity modifying protein 3 antibody|CRLR activity modifying protein 3 antibody|CRLR activity-modifying protein 3 antibody|OTTHUMP00000159549 antibody|OTTHUMP00000214279 antibody|OTTHUMP00000214280 antibody|Receptor (calcitonin) activity modifying protein 3 antibody|Receptor (G protein-coupled) activity modifying protein 3 antibody|Receptor activity modifying protein 3 antibody|Anti-RAMP3 antibody (ab78017)

SCBT cat No: sc-8855|sc-365313|sc-11381|sc-8854|

Name

Rabbit polyclonal RAMP3 antibody

Catalogue No.

A6715

Reactivity

Human

Immunogen

Recombinant protein of human RAMP3

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 16kDa/Observed: Refer to figures

Formulation

RAMP3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RAMP3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:O60896

Protein function

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Protein tissue specificity

Strongly expressed in lung, breast, immune system and fetal tissues.

Protein sequence and domain

Belongs to the RAMP family.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Membrane ; Single-pass type I membrane protein . Note: Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Background

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.

Note

AntibodyPlus can customize RAMP3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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