Rabbit polyclonal RAN antibody (A0976)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,RIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RAN antibody (A0976)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,RIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:20 – 1:50 RIP 1:20 – 1:50

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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RAN antibody,ARA24 antibody,Gsp1 antibody,TC4 antibody
Androgen receptor associated protein 24 antibody|Ras-like protein TC4 antibody|RASL2 8 antibody|TC 4 antibody|TC4 antibody|Anti-Ran antibody (ab53775)

SCBT cat No: sc-271376|sc-58467|sc-1156|sc-20802|sc-1155|

Name

Rabbit polyclonal RAN antibody

Catalogue No.

A0976

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RAN

Host

Rabbit

Applications

WB, IHC, IF, IP, RIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:20 – 1:50
RIP 1:20 – 1:50

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 25kDa/Observed: Refer to Figures

Formulation

RAN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RAN antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RAN antibody,ARA24 antibody,Gsp1 antibody,TC4 antibody

Database links

Human UniProt/Swiss-Prot:P62826

Protein names

RAN,ARA24,Gsp1,TC4

Protein function

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.; Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.

Protein tissue specificity

Expressed in a variety of tissues.

Protein sequence and domain

Belongs to the small GTPase superfamily. Ran family.

Protein cellular localization

Nucleus. Cytoplasm. Melanosome. Nucleus envelope . Note: Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis. Colocalizes with NEMP1 at the nuclear envelope (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Background

Ran is a small GTPase of the Ras family that plays a central role in the spacial and temperal organization of eukaryotic cells. During interphase, Ran-GDP localizes to the cytoplasm and Ran-GTP to the nucleus. This polarized localization of Ran ensures its role in nuclear transport (1). During mitosis, Ran-GTP is chromatin associated, where it promotes spindle assembly and nuclear envolope formation (1,2). In S phase, Ran-GTP associates with and inhibits MCM helicase, ensuring precise chromosomal DNA duplication during the cell cycle (3)

Research area

All research areas>GDP/GTP Binding Proteins>Ran
(View all antibody categories related to GDP/GTP Binding Proteins)

Note

AntibodyPlus can customize RAN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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