Rabbit polyclonal RANGAP1 antibody (A5381)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RANGAP1 antibody (A5381)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RANGAP1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

SD antibody, Fug1 antibody, RANGAP antibody
Fug 1 antibody|Fug1 antibody|GTPase-activating protein, RAN, 1 antibody|KIAA1835 antibody|MGC20266 antibody|OTTHUMP00000028918 antibody|OTTHUMP00000198755 antibody|OTTHUMP00000198756 antibody|OTTHUMP00000198757 antibody|OTTHUMP00000198758 antibody|RAGP1_HUMAN antibody|Ran 1 antibody|RAN GTPase activating protein 1 antibody|Ran GTPase-activating protein 1 antibody|Ran1 antibody|RANGAP 1 antibody|RANGAP antibody|RanGAP1 antibody|SD antibody|Segregation distorter homolog antibody|Segregation distortion antibody|Anti-RanGAP1 antibody [EPR3295] (ab92360)

SCBT cat No: sc-28322|sc-25630|sc-1862|

Name

Rabbit polyclonal RANGAP1 antibody

Catalogue No.

A5381

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RANGAP1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 63kDa/Observed: Refer to Figures

Formulation

RANGAP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RANGAP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SD antibody, Fug1 antibody, RANGAP antibody

Database links

Human UniProt/Swiss-Prot:P46060

Protein names

SD, Fug1, RANGAP

Protein function

GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.

Protein tissue specificity

Highly expressed in brain, thymus and testis.

Protein sequence and domain

Belongs to the RNA1 family.; Contains 6 LRR (leucine-rich) repeats.

Protein post-translational modifications

Phosphorylated occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBC9, on nuclear pore complex (NPC) diassembly and during mitosis.; Sumoylated with SUMO1. Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis. Also required for interaction with RANBP2 and is mediated by UBC9.

Protein cellular localization

Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle pole . Note: Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.

Background

This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants.

Note

AntibodyPlus can customize RANGAP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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