Rabbit polyclonal RAPGEF3 antibody (A2199)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RAPGEF3 antibody (A2199)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RAPGEF3 antibody.

Alternative names:

Check alternative names for the antibody

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CAMP-GEFI antibody, EPAC antibody, EPAC1 antibody, HSU79275 antibody, MGC21410 antibody, bcm910 antibody
bcm910 antibody|CAMP GEFI antibody|cAMP regulated guanine nucleotide exchange factor I antibody|CAMPGEFI antibody|CGEF 1 antibody|CGEF1 antibody|EPA1 antibody|Epac 1 antibody|EPAC antibody|EPAC1 antibody|Exchange factor directly activated by cAMP 1 antibody|Exchange protein directly activated by cAMP 1 antibody|MGC21410 antibody|RAP guanine nucleotide exchange factor antibody|Rap guanine nucleotide exchange factor (GEF) 3 antibody|RAP guanine nucleotide exchange factor 3 antibody|Rap1 guanine nucleotide exchange factor directly activated by cAMP antibody|RAPGEF3 antibody|Anti-Epac1 antibody (ab21236)

SCBT cat No: sc-28366|sc-8880|sc-25632|sc-8879|

Name

Rabbit polyclonal RAPGEF3 antibody

Catalogue No.

A2199

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RAPGEF3

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 99kDa/Observed: Refer to Figures

Formulation

RAPGEF3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RAPGEF3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CAMP-GEFI antibody, EPAC antibody, EPAC1 antibody, HSU79275 antibody, MGC21410 antibody, bcm910 antibody

Database links

Human UniProt/Swiss-Prot:O95398

Protein names

CAMP-GEFI, EPAC, EPAC1, HSU79275, MGC21410, bcm910

Protein function

Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.

Protein tissue specificity

Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.

Protein sequence and domain

The DEP domain is involved in membrane localization independent from regulation by cAMP.Contains 1 cyclic nucleotide-binding domain.; Contains 1 DEP domain.; Contains 1 N-terminal Ras-GEF domain.; Contains 1 Ras-GEF domain.

Protein cellular localization

Endomembrane system .

Background

EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA) (reviewed in 1). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation (2), exocytosis (3), insulin signaling (4), axon growth and guidance (5) and neurotransmitter release (6).

Research area

All research areas>GDP/GTP Binding Proteins>Epac
(View all antibody categories related to GDP/GTP Binding Proteins)

Note

AntibodyPlus can customize RAPGEF3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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