Rabbit polyclonal RASGRF1 antibody (A6964)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RASGRF1 antibody (A6964)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RASGRF1 antibody.

Alternative names:

Check alternative names for the antibody

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GNRP antibody, GRF1 antibody, CDC25 antibody, GRF55 antibody, CDC25L antibody, H-GRF55 antibody, PP13187 antibody, ras-GRF1 antibody
CDC25 antibody|CDC25L antibody|GNRP antibody|GRF1 antibody|GRF55 antibody|Guanine nucleotide exchange factor antibody|Guanine nucleotide releasing factor 55 kD antibody|Guanine nucleotide releasing protein antibody|guanine nucleotide-releasing factor 1 antibody|Guanine nucleotide-releasing protein antibody|H GRF55 antibody|HGRF55 antibody|PP13187 antibody|Ras protein specific guanine nucleotide releasing factor 1 antibody|Ras specific guanine nucleotide releasing factor antibody|Ras specific guanine nucleotide releasing factor CDC25 homolog antibody|Ras specific nucleotide exchange factor CDC25 antibody|Ras-GRF1 antibody|Ras-specific guanine nucleotide-releasing factor 1 antibody|Ras-specific nucleotide exchange factor CDC25 antibody|RASGRF1 antibody|RGRF1_HUMAN antibody|Anti-RASGRF1 antibody (ab94722)

SCBT cat No: sc-130215|sc-515151|sc-514307|sc-56174|sc-135776|sc-56175|

Name

Rabbit polyclonal RASGRF1 antibody

Catalogue No.

A6964

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human RASGRF1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 145kDa/Observed: Refer to figures

Formulation

RASGRF1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RASGRF1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GNRP antibody, GRF1 antibody, CDC25 antibody, GRF55 antibody, CDC25L antibody, H-GRF55 antibody, PP13187 antibody, ras-GRF1 antibody

Database links

Human UniProt/Swiss-Prot:Q13972

Protein names

GNRP, GRF1, CDC25, GRF55, CDC25L, H-GRF55, PP13187, ras-GRF1

Protein function

Promotes the exchange of Ras-bound GDP by GTP.

Protein sequence and domain

The DH (DBL-homology) domain mediates interaction with RASGRF2.Contains 1 DH (DBL-homology) domain.; Contains 1 IQ domain.; Contains 1 N-terminal Ras-GEF domain.; Contains 2 PH domains.; Contains 1 Ras-GEF domain.

Protein post-translational modifications

Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome.; Ubiquitinated and degraded following phosphorylation by PLK2.; Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.

Background

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Research area

All research areas>GDP/GTP Binding Proteins>Ras
(View all antibody categories related to GDP/GTP Binding Proteins)

Note

AntibodyPlus can customize RASGRF1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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