Rabbit polyclonal RASSF5 antibody (A7389)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RASSF5 antibody (A7389)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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RAPL antibody, Maxp1 antibody, NORE1 antibody, NORE1A antibody, NORE1B antibody, RASSF3 antibody
Maxp 1 antibody|MAXP1 antibody|MGC10823 antibody|MGC17344 antibody|New ras effector 1 antibody|NORE 1 antibody|NORE1A antibody|NORE1B antibody|Novel Ras effector 1 antibody|RAP1 Binding Protein antibody|RAPL antibody|Ras association (RalGDS/AF 6) domain family 5 antibody|Ras association (RalGDS/AF 6) domain family member 5 antibody|Ras association domain containing family protein 5 antibody|Ras association domain-containing protein 5 antibody|Ras effector like protein antibody|RASF5_HUMAN antibody|RASSF 3 antibody|RASSF 5 antibody|RASSF3 antibody|RASSF5 antibody|Regulator for cell adhesion and polarization enriched in lymphoid tissue antibody|Regulator for cell adhesion and polarization enriched in lymphoid tissues antibody|Tumor suppressor RASSF3 antibody|Anti-NORE1 antibody (ab22770)

SCBT cat No: sc-80017|

Name

Rabbit polyclonal RASSF5 antibody

Catalogue No.

A7389

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RASSF5

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 47kDa/Observed: Refer to figures

Formulation

RASSF5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RASSF5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RAPL antibody, Maxp1 antibody, NORE1 antibody, NORE1A antibody, NORE1B antibody, RASSF3 antibody

Database links

Human UniProt/Swiss-Prot:Q8WWW0

Protein names

RAPL, Maxp1, NORE1, NORE1A, NORE1B, RASSF3

Protein function

Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Protein tissue specificity

Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.

Protein sequence and domain

Contains 1 phorbol-ester/DAG-type zinc finger.; Contains 1 Ras-associating domain.; Contains 1 SARAH domain.

Protein cellular localization

Cytoplasm. Cytoplasm, cytoskeleton. Note: Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.

Background

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize RASSF5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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