Rabbit polyclonal RBBP4 antibody (A1490)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,ChIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RBBP4 antibody (A1490)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,ChIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:50 – 1:200 ChIP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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NURF55 antibody, RBAP48 antibody
CAF I p48 antibody|CAF-1 subunit C antibody|CAF-I 48 kDa subunit antibody|CAF-I p48 antibody|Chromatin assembly factor 1 subunit C antibody|Chromatin assembly factor I p48 subunit antibody|Chromatin assembly factor/CAF 1 p48 subunit antibody|Histone-binding protein RBBP4 antibody|MSI1 protein homolog antibody|Nucleosome-remodeling factor subunit RBAP48 antibody|NURF55 antibody|RbAp 48 antibody|RBAP48 antibody|RBBP-4 antibody|RBBP4 antibody|RBBP4_HUMAN antibody|Retinoblastoma binding protein 4 antibody|Retinoblastoma binding protein p48 antibody|Retinoblastoma-binding protein 4 antibody|Retinoblastoma-binding protein p48 antibody|Anti-RbAp48 antibody (ab1765)

SCBT cat No: sc-373873|sc-33170|sc-12434|sc-8270|

Name

Rabbit polyclonal RBBP4 antibody

Catalogue No.

A1490

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RBBP4

Host

Rabbit

Applications

WB, IHC, IF, IP, ChIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:50 – 1:200
ChIP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 48kDa/Observed: Refer to Figures

Formulation

RBBP4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RBBP4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NURF55 antibody, RBAP48 antibody

Database links

Human UniProt/Swiss-Prot:Q09028

Protein names

NURF55, RBAP48

Protein function

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Protein sequence and domain

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.; Contains 6 WD repeats.

Protein cellular localization

Nucleus.

Background

Retinoblastoma-associated proteins 46 and 48 (RBAP46 and RBAP48; also known as RBBP7 and RBBP4) were first characterized in human cells as proteins that bind to the retinoblastoma (Rb) tumor suppressor protein (1). Since then, these proteins have been shown to be components of many protein complexes involved in chromatin regulation, including the chromatin assembly factor 1 (CAF-1) complex and type B histone acetyltransferase complex HAT1, both of which function in chromatin assembly during DNA replication (2,3). RBAP46 and RBAP48 are also found in the nucleosome remodeling factor complex NURF, the nucleosome remodeling and histone de-acetylation complex NuRD, and the Sin3/HDAC histone de-acetylation complex (4-7). More recently, RBAP46 and RBAP48 were identified as components of the polycomb repressor complex PRC2, which also contains EED and Ezh2 (8). RBAP46 and RBAP48 bind to the histone fold region of histone H4 and are believed to target these chromatin remodeling, histone acetylation, and histone de-acetylation complexes to their histone substrates (3).

Note

AntibodyPlus can customize RBBP4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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