Rabbit polyclonal RELB antibody (A0519)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RELB antibody (A0519)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RELB antibody.

Alternative names:

Check alternative names for the antibody

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IREL antibody, I-REL antibody, REL-B antibody
I REL antibody|I-Rel antibody|IREL antibody|Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 antibody|relB antibody|RELB_HUMAN antibody|Reticuloendotheliosis viral oncogene homolog B antibody|Transcription factor Rel B antibody|Transcription factor RelB antibody|v rel avian reticuloendotheliosis viral oncogene homolog B antibody|v rel reticuloendotheliosis viral oncogene homolog B antibody|Anti-Rel B antibody [EPR7076] – C-terminal (ab180127)

SCBT cat No: sc-101792|sc-390191|sc-100817|sc-366193|sc-160082|sc-365416|sc-98504|sc-82324|sc-25282|sc-55471|

Name

Rabbit polyclonal RELB antibody

Catalogue No.

A0519

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human RELB

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 70kDa/Observed: Refer to Figures

Formulation

RELB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RELB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IREL antibody, I-REL antibody, REL-B antibody

Database links

Human UniProt/Swiss-Prot:Q01201

Protein names

IREL, I-REL, REL-B

Protein function

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52.

Protein sequence and domain

Both N- and C-terminal domains are required for transcriptional activation.Contains 1 RHD (Rel-like) domain.

Protein post-translational modifications

Phosphorylation at ‘Thr-103’ and ‘Ser-573’ is followed by proteasomal degradation.

Protein cellular localization

Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Note: Colocalizes with NEK6 in the centrosome.

Background

RelB, also known as I-Rel, is a member of the Rel transcription factor family which also include; RelA-p65, c-Rel, NF-kB1 p100/52 and NF-kB2 p105/50. Unlike other Rel-related protein, RelB does not bind to DNA or to inhibitor IkB, but is instead sequestered in the cytoplasm by precursor p100. Once p100 is processed, the p52/RelB complex translocates into the nucleus. RelB is also the transcription factor that has been associated most directly with dendritic cells (DCs) differentiation and function. It is upregulated and translocated into the nuclei of DC in response to various stimuli. RelB is also essential for generating a specific DC subset (CD11c +/CD11b +/CD8 -/Dec205 -) from hematopoietic stem cells.

Research area

All research areas>Transcription Regulators>RelB
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize RELB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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