Rabbit polyclonal RHOC antibody (A1062)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal RHOC antibody (A1062)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RHOC antibody.

Alternative names:

Check alternative names for the antibody

Expand

RHOC antibody,ARH9 antibody,ARHC antibody,H9 antibody,MGC1448 antibody,MGC61427 antibody,RHOH9 antibody
rhoC antibody|RhoC GTPase antibody|RHOC_HUMAN antibody|RHOH 9 antibody|RHOH9 antibody|Small GTP binding protein RhoC antibody|Anti-RHOC antibody [2E12] (ab54837)

SCBT cat No: sc-166399|sc-28565|sc-180|sc-8048|

Name

Rabbit polyclonal RHOC antibody

Catalogue No.

A1062

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RHOC

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 22kDa/Observed: Refer to Figures

Formulation

RHOC antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RHOC antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RHOC antibody,ARH9 antibody,ARHC antibody,H9 antibody,MGC1448 antibody,MGC61427 antibody,RHOH9 antibody

Database links

Human UniProt/Swiss-Prot:P08134

Protein names

RHOC,ARH9,ARHC,H9,MGC1448,MGC61427,RHOH9

Protein function

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.

Protein sequence and domain

Belongs to the small GTPase superfamily. Rho family.

Protein post-translational modifications

(Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.

Protein cellular localization

Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cleavage furrow . Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Background

Rho family small GTPases, including Rho, Rac and cdc42, act as molecular switches, regulating processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP. A third level of regulation is provided by the stoichiometric binding of Rho GDP dissociation inhibitor (RhoGDI) (1). RhoA, RhoB and RhoC are highly homologous, but appear to have divergent biological functions. Carboxy-terminal modifications and differences in subcellular localization allow these three proteins to respond to and act on distinct signaling molecules (2,3).

Research area

All research areas>GDP/GTP Binding Proteins>Rho
(View all antibody categories related to GDP/GTP Binding Proteins)

Note

AntibodyPlus can customize RHOC antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!