Rabbit polyclonal RIPK2 antibody (A2498)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal RIPK2 antibody (A2498)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RIPK2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

CCK antibody, RICK antibody, RIP2 antibody, CARD3 antibody, GIG30 antibody, CARDIAK antibody
CARD 3 antibody|CARD carrying kinase antibody|CARD containing ICE associated kinase antibody|CARD containing IL 1 beta ICE kinase antibody|CARD containing IL1 beta ICE kinase antibody|CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase antibody|CARD containing interleukin 1 beta converting enzyme associated kinase antibody|CARD-containing IL-1 beta ICE-kinase antibody|CARD-containing interleukin-1 beta-converting enzyme-associated kinase antibody|CARD3 antibody|CARDIAK antibody|CCK antibody|CLARP kinase antibody|GIG 30 antibody|GIG30 antibody|Growth inhibiting gene 30 antibody|Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase antibody|Receptor interacting protein 2 antibody|Receptor interacting serine threonine kinase 2 antibody|Receptor interacting serine/threonine protein kinase 2 antibody|Receptor-interacting protein 2 antibody|Receptor-interacting serine/threonine-protein kinase 2 antibody|RICK antibody|RIP 2 antibody|RIP like interacting CLARP kinase antibody|RIP-2 antibody|RIP-like-interacting CLARP kinase antibody|RIPK 2 antibody|Ripk2 antibody|RIPK2_HUMAN antibody|TNFRSF antibody|Tyrosine-protein kinase RIPK2 antibody|UNQ277/PRO314/PRO34092 antibody|Anti-RIP2 antibody (ab8428)

SCBT cat No: sc-136059|sc-166765|sc-22763|sc-8610|

Name

Rabbit polyclonal RIPK2 antibody

Catalogue No.

A2498

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RIPK2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 61kDa/Observed: Refer to Figures

Formulation

RIPK2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RIPK2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CCK antibody, RICK antibody, RIP2 antibody, CARD3 antibody, GIG30 antibody, CARDIAK antibody

Database links

Human UniProt/Swiss-Prot:O43353

Protein names

CCK, RICK, RIP2, CARD3, GIG30, CARDIAK

Protein function

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes ‘Lys-63’-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces ‘Lys-63’-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

Protein tissue specificity

Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.

Protein sequence and domain

Contains an N-terminal kinase domain and a C-terminal caspase activation and recruitment domain (CARD) that mediates the recruitment of CARD-containing proteins.Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.; Contains 1 CARD domain.; Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated. Autophosphorylation at Tyr-474 is necessary for effective NOD2 signaling. Phosphorylated. Phosphorylation at Tyr-381 by Src kinase CSK occurs in a ARHGEF2-dependent manner and is required for NOD2-dependent innate immune activation.; Ubiquitinated on Lys-209; undergoes ‘Lys-63’-linked polyubiquitination catalyzed by ITCH. Polyubiquitinated with ‘Lys-48’ and ‘Lys-63’-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. Also undergoes ‘Met-1’-linked polyubiquitination; the head-to-tail linear polyubiquitination is mediated by the LUBAC complex in response to NOD2 stimulation. Linear polyubiquitination is restricted by FAM105B/otulin, probably to limit NOD2-dependent proinflammatory signaling activation of NF-kappa-B.

Protein cellular localization

Cytoplasm .

Background

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.

Note

AntibodyPlus can customize RIPK2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!