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Rabbit polyclonal RNASEL antibody (A9840)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal RNASEL antibody.
Check alternative names for the antibodyExpand
2 5A dependent ribonuclease antibody|2 5A dependent RNase antibody|2′ 5′ oligoisoadenylate synthetase dependent antibody|2-5A-dependent ribonuclease antibody|2-5A-dependent RNase antibody|DKFZp781D08126 antibody|Interferon induced 2 5A dependent RNase antibody|MGC104972 antibody|MGC133329 antibody|PRCA 1 antibody|PRCA1 antibody|Ribonuclease 4 antibody|Ribonuclease L (2′ 5′ oligoisoadenylate synthetase dependent) antibody|Ribonuclease L antibody|Ribonuclease4 antibody|RibonucleaseL antibody|RN5A_HUMAN antibody|RNase L antibody|Rnasel antibody|RNS 4 antibody|RNS4 antibody|Anti-RNase L [EPR15894] antibody (ab191392)
SCBT cat No: sc-23955|sc-22870|sc-74405|sc-25798|sc-74416|sc-22873|
Rabbit polyclonal RNASEL antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human RNASEL
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 84kDa/Observed: Refer to figures
RNASEL antibody was tube-contained.
RNASEL antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis . Might play a central role in the regulation of mRNA turnover .
|Protein tissue specificity|| |
Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
|Protein sequence and domain|| |
The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain.; The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.; The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity (By similarity).Belongs to the protein kinase superfamily.; Contains 9 ANK repeats.; Contains 1 KEN domain.; Contains 1 protein kinase domain.
|Protein cellular localization|| |
Cytoplasm . Mitochondrion .
AntibodyPlus can customize RNASEL antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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