Rabbit polyclonal RNASEL antibody (A9840)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal RNASEL antibody (A9840)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RNASEL antibody.

Alternative names:

Check alternative names for the antibody

Expand

2 5A dependent ribonuclease antibody|2 5A dependent RNase antibody|2′ 5′ oligoisoadenylate synthetase dependent antibody|2-5A-dependent ribonuclease antibody|2-5A-dependent RNase antibody|DKFZp781D08126 antibody|Interferon induced 2 5A dependent RNase antibody|MGC104972 antibody|MGC133329 antibody|PRCA 1 antibody|PRCA1 antibody|Ribonuclease 4 antibody|Ribonuclease L (2′ 5′ oligoisoadenylate synthetase dependent) antibody|Ribonuclease L antibody|Ribonuclease4 antibody|RibonucleaseL antibody|RN5A_HUMAN antibody|RNase L antibody|Rnasel antibody|RNS 4 antibody|RNS4 antibody|Anti-RNase L [EPR15894] antibody (ab191392)

SCBT cat No: sc-23955|sc-22870|sc-74405|sc-25798|sc-74416|sc-22873|

Name

Rabbit polyclonal RNASEL antibody

Catalogue No.

A9840

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RNASEL

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 84kDa/Observed: Refer to figures

Formulation

RNASEL antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RNASEL antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q05823

Protein function

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis . Might play a central role in the regulation of mRNA turnover .

Protein tissue specificity

Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Protein sequence and domain

The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain.; The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.; The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity (By similarity).Belongs to the protein kinase superfamily.; Contains 9 ANK repeats.; Contains 1 KEN domain.; Contains 1 protein kinase domain.

Protein cellular localization

Cytoplasm . Mitochondrion .

Research area

All research areas>Transcription Regulators>RNase
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize RNASEL antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!