Rabbit polyclonal RNF2 antibody (A5563)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,ChIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal RNF2 antibody (A5563)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,ChIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:50 – 1:200 ChIP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RNF2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

BAP1 antibody, DING antibody, BAP-1 antibody, HIPI3 antibody, RING2 antibody, RING1B antibody
BAP 1 antibody|BAP1 antibody|DING antibody|DinG protein antibody|E3 ubiquitin protein ligase RING 2 antibody|E3 ubiquitin protein ligase RING2 antibody|E3 ubiquitin-protein ligase RING2 antibody|HIP2 interacting protein 3 antibody|HIP2-interacting protein 3 antibody|HIPI 3 antibody|HIPI3 antibody|Huntingtin interacting protein 2 interacting protein 3 antibody|Huntingtin-interacting protein 2-interacting protein 3 antibody|OTTHUMP00000060668 antibody|Polycomb M33 interacting protein Ring 1B antibody|Polycomb M33 interacting protein Ring1B antibody|Protein DinG antibody|RING 1B antibody|RING 2 antibody|RING finger protein 1B antibody|RING finger protein 2 antibody|RING finger protein BAP 1 antibody|RING finger protein BAP-1 antibody|RING finger protein BAP1 antibody|RING1b antibody|RING2_HUMAN antibody|RNF 2 antibody|Rnf2 antibody|Anti-RING2 / RING1B / RNF2 antibody – ChIP Grade (ab3832)

SCBT cat No: sc-101109|

Name

Rabbit polyclonal RNF2 antibody

Catalogue No.

A5563

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RNF2

Host

Rabbit

Applications

WB, IHC, IF, IP, ChIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:50 – 1:200
ChIP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 37kDa/Observed: Refer to Figures

Formulation

RNF2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RNF2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BAP1 antibody, DING antibody, BAP-1 antibody, HIPI3 antibody, RING2 antibody, RING1B antibody

Database links

Human UniProt/Swiss-Prot:Q99496

Protein names

BAP1, DING, BAP-1, HIPI3, RING2, RING1B

Protein function

E3 ubiquitin-protein ligase that mediates monoubiquitination of ‘Lys-119’ of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.

Protein sequence and domain

Contains 1 RING-type zinc finger.

Protein post-translational modifications

Polyubiquitinated in the presence of UBE2D3 (in vitro).; Monoubiquitinated, by auto-ubiquitination.

Protein cellular localization

Nucleus . Chromosome . Note: Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (By similarity).

Background

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.

Note

AntibodyPlus can customize RNF2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!