Rabbit polyclonal RNF31 antibody (A8227)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RNF31 antibody (A8227)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RNF31 antibody.

Alternative names:

Check alternative names for the antibody

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HOIP antibody, ZIBRA antibody
E3 ubiquitin protein ligase RNF31 antibody|FLJ10111 antibody|FLJ23501 antibody|HOIL 1L interacting protein antibody|HOIL-1-interacting protein antibody|HOIL1L interacting protein antibody|HOIP antibody|RING finger protein 31 antibody|RNF31 antibody|RNF31_HUMAN antibody|ZIBRA antibody|Zinc in between ring finger ubiquitin associated domain antibody|Zinc in-between-RING-finger ubiquitin-associated domain protein antibody|Anti-RNF31/HOIP antibody (ab85294)

SCBT cat No:

Name

Rabbit polyclonal RNF31 antibody

Catalogue No.

A8227

Reactivity

Human

Immunogen

Recombinant protein of human RNF31

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 120kDa/Observed: Refer to figures

Formulation

RNF31 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RNF31 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HOIP antibody, ZIBRA antibody

Database links

Human UniProt/Swiss-Prot:Q96EP0

Protein names

HOIP, ZIBRA

Protein function

E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear (‘Met-1’-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

Protein tissue specificity

Expressed in both normal and transformed breast epithelial cell lines.

Protein sequence and domain

The RanBP2-type zinc fingers mediate the specific interaction with ubiquitin.; The UBA domain mediates association with RBCK1/HOIL1 via interaction with its UBL domain.; RING 1 and IBR zinc-fingers catalyze the first step transfer of ubiquitin from the E2 onto RING 2, to transiently form a HECT-like covalent thioester intermediate.; The linear ubiquitin chain determining domain (LDD) mediates the final transfer of ubiquitin from RING 2 onto the N-terminus of a target ubiquitin.Contains 1 IBR-type zinc finger.; Contains 3 RanBP2-type zinc fingers.; Contains 2 RING-type zinc fingers.; Contains 1 UBA domain.

Protein cellular localization

Cytoplasm .

Background

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.

Research area

All research areas>Transcription Regulators>RNF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize RNF31 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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