Rabbit polyclonal RNF34 antibody (A8517)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RNF34 antibody (A8517)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RNF34 antibody.

Alternative names:

Check alternative names for the antibody

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RFI antibody, RIF antibody, RIFF antibody, hRFI antibody, CARP1 antibody, CARP-1 antibody
CARP 1 antibody|CARP-1 antibody|CARP1 antibody|Caspase regulator CARP1 antibody|Caspases-8 and -10-associated RING finger protein 1 antibody|E3 ubiquitin-protein ligase RNF34 antibody|FYVE-RING finger protein Momo antibody|hRFI antibody|Human RING finger homologous to inhibitor of apoptosis protein antibody|RFI antibody|RIF antibody|RIFF antibody|RING finger protein 34 antibody|RING finger protein RIFF antibody|RNF34 antibody|RNF34_HUMAN antibody|Anti-RNF34 antibody (ab117084)

SCBT cat No:

Name

Rabbit polyclonal RNF34 antibody

Catalogue No.

A8517

Reactivity

Human

Immunogen

Recombinant protein of human RNF34

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 42kDa/Observed: Refer to figures

Formulation

RNF34 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RNF34 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RFI antibody, RIF antibody, RIFF antibody, hRFI antibody, CARP1 antibody, CARP-1 antibody

Database links

Human UniProt/Swiss-Prot:Q969K3

Protein names

RFI, RIF, RIFF, hRFI, CARP1, CARP-1

Protein function

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis . May mediate ‘Lys-48’-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation . Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN . Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells . Possibly involved in innate immunity, through ‘Lys-48’-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation .

Protein tissue specificity

Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes.

Protein sequence and domain

The RING-type zinc finger is required for the ubiquitination of target proteins.; The FYVE-type zinc finger domain is required for localization and may confer affinity for cellular compartments enriched in phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate phospholipids.Contains 1 FYVE-type zinc finger.; Contains 1 RING-type zinc finger.; Contains 2 SAP domains.

Protein post-translational modifications

Autoubiquitinated (in vitro).; Proteolytically cleaved by caspases upon induction of apoptosis by TNF.

Protein cellular localization

Cell membrane ; Peripheral membrane protein . Endomembrane system ; Peripheral membrane protein . Nucleus . Nucleus speckle . Cytoplasm, cytosol .

Background

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.

Research area

All research areas>Transcription Regulators>RNF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize RNF34 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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