Rabbit polyclonal RNF40 antibody (A6443)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RNF40 antibody (A6443)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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BRE1B antibody, RBP95 antibody, STARING antibody
95 kDa retinoblastoma associated protein antibody|95 kDa retinoblastoma protein binding protein antibody|95 kDa retinoblastoma-associated protein antibody|BRE 1B antibody|BRE1 B antibody|BRE1 E3 ubiquitin ligase homolog B antibody|BRE1-B antibody|BRE1B antibody|BRE1B_HUMAN antibody|DKFZp686K191 antibody|E3 ubiquitin protein ligase BRE1B antibody|E3 ubiquitin-protein ligase BRE1B antibody|KIAA0661 antibody|MGC13051 antibody|Rb associated protein antibody|RBP 95 antibody|RBP95 antibody|RING finger protein 40 antibody|Ring finger protein 40 E3 ubiquitin protein ligase antibody|RNF 40 antibody|Rnf40 antibody|STARING antibody|Anti-RNF40 antibody [EPR18511] (ab191309)

SCBT cat No: sc-293333|sc-292445|sc-132079|

Name

Rabbit polyclonal RNF40 antibody

Catalogue No.

A6443

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RNF40

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 113kDa/Observed: Refer to Figures

Formulation

RNF40 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RNF40 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BRE1B antibody, RBP95 antibody, STARING antibody

Database links

Human UniProt/Swiss-Prot:O75150

Protein names

BRE1B, RBP95, STARING

Protein function

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ‘Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ‘Lys-4’ and ‘Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.

Protein tissue specificity

Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.

Protein sequence and domain

Belongs to the BRE1 family.; Contains 1 RING-type zinc finger.

Protein cellular localization

Nucleus .

Background

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Transcription Regulators>RNF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize RNF40 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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