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Rabbit polyclonal RPE65 antibody (A9841)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal RPE65 antibody.
Check alternative names for the antibodyExpand
All-trans-retinyl-palmitate hydrolase antibody|LCA 2 antibody|LCA2 antibody|Leber congenital amaurosis antibody|mRPE 65 antibody|mRPE65 antibody|p63 antibody|rd 12 antibody|rd12 antibody|Retinal pigment epithelium specific 61 kDa protein antibody|Retinal pigment epithelium specific 65 kDa protein antibody|Retinal pigment epithelium specific protein antibody|Retinal pigment epithelium specific protein 65kDa antibody|Retinal pigment epithelium-specific 65 kDa protein antibody|Retinitis pigmentosa 20 antibody|Retinoid isomerohydrolase antibody|Retinol isomerase antibody|RP 20 antibody|RP20 antibody|RPE 65 antibody|RPE65 antibody|RPE65_HUMAN antibody|sRPE 65 antibody|sRPE65 antibody|Anti-RPE65 antibody [401.8B11.3D9] (ab78036)
SCBT cat No: sc-73616|sc-53489|sc-33294|sc-390787|sc-32893|
Rabbit polyclonal RPE65 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human RPE65
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 61kDa/Observed: Refer to figures
RPE65 antibody was tube-contained.
RPE65 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.
|Protein tissue specificity|| |
Retinal pigment epithelium specific.
|Protein sequence and domain|| |
Belongs to the carotenoid oxygenase family.
|Protein post-translational modifications|| |
Palmitoylation by LRAT regulates ligand binding specificity; the palmitoylated form (membrane form) specifically binds all-trans-retinyl-palmitate, while the soluble unpalmitoylated form binds all-trans-retinol (vitamin A).
|Protein cellular localization|| |
Cytoplasm . Cell membrane ; Lipid-anchor . Microsome membrane . Note: Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated (By similarity). Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells.
AntibodyPlus can customize RPE65 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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