Rabbit polyclonal RPE65 antibody (A9841)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RPE65 antibody (A9841)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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All-trans-retinyl-palmitate hydrolase antibody|LCA 2 antibody|LCA2 antibody|Leber congenital amaurosis antibody|mRPE 65 antibody|mRPE65 antibody|p63 antibody|rd 12 antibody|rd12 antibody|Retinal pigment epithelium specific 61 kDa protein antibody|Retinal pigment epithelium specific 65 kDa protein antibody|Retinal pigment epithelium specific protein antibody|Retinal pigment epithelium specific protein 65kDa antibody|Retinal pigment epithelium-specific 65 kDa protein antibody|Retinitis pigmentosa 20 antibody|Retinoid isomerohydrolase antibody|Retinol isomerase antibody|RP 20 antibody|RP20 antibody|RPE 65 antibody|RPE65 antibody|RPE65_HUMAN antibody|sRPE 65 antibody|sRPE65 antibody|Anti-RPE65 antibody [401.8B11.3D9] (ab78036)

SCBT cat No: sc-73616|sc-53489|sc-33294|sc-390787|sc-32893|

Name

Rabbit polyclonal RPE65 antibody

Catalogue No.

A9841

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RPE65

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 61kDa/Observed: Refer to figures

Formulation

RPE65 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RPE65 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q16518

Protein function

Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.

Protein tissue specificity

Retinal pigment epithelium specific.

Protein sequence and domain

Belongs to the carotenoid oxygenase family.

Protein post-translational modifications

Palmitoylation by LRAT regulates ligand binding specificity; the palmitoylated form (membrane form) specifically binds all-trans-retinyl-palmitate, while the soluble unpalmitoylated form binds all-trans-retinol (vitamin A).

Protein cellular localization

Cytoplasm . Cell membrane ; Lipid-anchor . Microsome membrane . Note: Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated (By similarity). Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells.

Note

AntibodyPlus can customize RPE65 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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