Rabbit polyclonal RPGR antibody (A1844)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RPGR antibody (A1844)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

CRD antibody, RP3 antibody, COD1 antibody, PCDX antibody, RP15 antibody, XLRP3 antibody, orf15 antibody, CORDX1 antibody
COD1 antibody|Cone Dystrophy 1 (X-Linked) antibody|CORDX1 antibody|CRD antibody|Orf15 antibody|PCDX antibody|Retinitis Pigmentosa 15 antibody|Retinitis Pigmentosa GTPase Regulator antibody|RP15 antibody|RP3 antibody|RPGR antibody|RPGR_HUMAN antibody|X-linked retinitis pigmentosa GTPase regulator antibody|XLRP3 antibody|Anti-RPGR antibody – N-terminal (ab180729)

SCBT cat No: sc-14676|

Name

Rabbit polyclonal RPGR antibody

Catalogue No.

A1844

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RPGR

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 113kDa/Observed: Refer to Figures

Formulation

RPGR antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RPGR antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CRD antibody, RP3 antibody, COD1 antibody, PCDX antibody, RP15 antibody, XLRP3 antibody, orf15 antibody, CORDX1 antibody

Database links

Human UniProt/Swiss-Prot:Q92834

Protein names

CRD, RP3, COD1, PCDX, RP15, XLRP3, orf15, CORDX1

Protein function

Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia.

Protein tissue specificity

Heart, brain, placenta, lung, liver, muscle, kidney, retina, pancreas and fetal retinal pigment epithelium. Isoform 3 is found only in the retina. Colocalizes with RPGRIP1 in the outer segment of rod photoreceptors and cone outer segments.

Protein sequence and domain

The RCC1 repeat region mediates interactions with RPGRIP1.Contains 6 RCC1 repeats.

Protein post-translational modifications

Prenylated.

Protein cellular localization

Cytoplasm, cytoskeleton, flagellum axoneme . Golgi apparatus .; Isoform 6: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme.

Background

This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined. [provided by RefSeq, Dec 2008]

Note

AntibodyPlus can customize RPGR antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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