Rabbit polyclonal RRM2 antibody (A5255)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RRM2 antibody (A5255)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RRM2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

R2 antibody,RR2M antibody
cb111 antibody|chunp6884 antibody|etID309896.20 antibody|R2 antibody|reductase M2 polypeptide variant 1 antibody|reductase M2 polypeptide variant 2 antibody|reductase M2 polypeptide variant 3a antibody|reductase M2 polypeptide variant 3b antibody|reductase M2 polypeptide variant 3c antibody|reductase M2 polypeptide variant 3d antibody|Ribonucleoside-diphosphate reductase subunit M2 antibody|Ribonucleotide reductase M2 antibody|Ribonucleotide reductase M2 polypeptide antibody|Ribonucleotide reductase M2 subunit antibody|ribonucleotide reductase protein r2 class I antibody|Ribonucleotide reductase regulatory subunit M2 antibody|Ribonucleotide reductase small chain antibody|Ribonucleotide reductase small subunit antibody|Ribonucleotide reductase, R2 subunit antibody|RIR2_HUMAN antibody|RR2 antibody|RR2M antibody|RRM2 antibody|Anti-RRM2 antibody (ab57653)

SCBT cat No: sc-398294|sc-10846|sc-10848|sc-10844|sc-81850|

Name

Rabbit polyclonal RRM2 antibody

Catalogue No.

A5255

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RRM2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to Figures

Formulation

RRM2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RRM2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

R2 antibody,RR2M antibody

Database links

Human UniProt/Swiss-Prot:P31350

Protein names

R2,RR2M

Protein function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.

Protein sequence and domain

Belongs to the ribonucleoside diphosphate reductase small chain family.

Protein post-translational modifications

Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling.

Protein cellular localization

Cytoplasm.

Background

Ribonucleotide reductase M2 subunit is one of two subunits that constitute ribonucleotide reductase, the enzyme that catalyzes the conversion of ribonucleotide 5′-diphosphates into 2′-deoxyribonucleotides, a rate-limiting step in the production of 2′-deoxyribonucleoside 5′-diphosphates (dNTP) required for DNA synthesis and repair that is required for DNA synthesis and repair [PMID:20825972, 19250552]. RRM2 is only expressed during the late G1/early S phase, and degraded in late S phase, and the activity of RNR, and therefore DNA synthesis and cell proliferation, is controlled during the cell cycle by the synthesis and degradation of RRM2 subunit.

Note

AntibodyPlus can customize RRM2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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