Rabbit polyclonal RSPO3 antibody (A8389)


Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RSPO3 antibody (A8389)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RSPO3 antibody.

Alternative names:

Check alternative names for the antibody


PWTSR antibody, THSD2 antibody, CRISTIN1 antibody
CRISTIN1 antibody|hPWTSR antibody|hRspo3 antibody|Protein with TSP type-1 repeat antibody|PWTSR antibody|R-spondin 3 homolog antibody|R-spondin-3 [Precursor] antibody|R-spondin-3 antibody|Roof plate specific spondin-3 antibody|Roof plate-specific spondin-3 antibody|RSPO3 antibody|RSPO3_HUMAN antibody|Thrombospondin type I domain containing 2 antibody|Thrombospondin type-1 domain-containing protein 2 antibody|THSD2 antibody|Anti-RSPO3 antibody (ab109808)

SCBT cat No: sc-107984|sc-107985|


Rabbit polyclonal RSPO3 antibody

Catalogue No.



Human, Mouse, Rat


A synthetic peptide of human RSPO3





Recommended dilution

WB 1:500 – 1:2000







Molecular weight

Predicted: 31kDa/Observed: Refer to figures


RSPO3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


RSPO3 antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PWTSR antibody, THSD2 antibody, CRISTIN1 antibody

Database links

Human UniProt/Swiss-Prot:Q9BXY4

Protein names


Protein function

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway . Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity).

Protein tissue specificity

Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node . Highly expressed in endothelial cells .

Protein sequence and domain

The FU repeats are required for activation and stabilization of beta-catenin.Belongs to the R-spondin family.; Contains 2 FU (furin-like) repeats.; Contains 1 TSP type-1 domain.

Protein cellular localization

Secreted .


This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development.

Research area

All research areas>Cell Adhesion Proteins>R-Spondin
(View all antibody categories related to Cell Adhesion Proteins)


AntibodyPlus can customize RSPO3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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