Rabbit polyclonal RSPO3 antibody (A8389)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RSPO3 antibody (A8389)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PWTSR antibody, THSD2 antibody, CRISTIN1 antibody
CRISTIN1 antibody|hPWTSR antibody|hRspo3 antibody|Protein with TSP type-1 repeat antibody|PWTSR antibody|R-spondin 3 homolog antibody|R-spondin-3 [Precursor] antibody|R-spondin-3 antibody|Roof plate specific spondin-3 antibody|Roof plate-specific spondin-3 antibody|RSPO3 antibody|RSPO3_HUMAN antibody|Thrombospondin type I domain containing 2 antibody|Thrombospondin type-1 domain-containing protein 2 antibody|THSD2 antibody|Anti-RSPO3 antibody (ab109808)

SCBT cat No: sc-107984|sc-107985|

Name

Rabbit polyclonal RSPO3 antibody

Catalogue No.

A8389

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human RSPO3

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 31kDa/Observed: Refer to figures

Formulation

RSPO3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RSPO3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PWTSR antibody, THSD2 antibody, CRISTIN1 antibody

Database links

Human UniProt/Swiss-Prot:Q9BXY4

Protein names

PWTSR, THSD2, CRISTIN1

Protein function

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway . Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity).

Protein tissue specificity

Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node . Highly expressed in endothelial cells .

Protein sequence and domain

The FU repeats are required for activation and stabilization of beta-catenin.Belongs to the R-spondin family.; Contains 2 FU (furin-like) repeats.; Contains 1 TSP type-1 domain.

Protein cellular localization

Secreted .

Background

This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development.

Research area

All research areas>Cell Adhesion Proteins>R-Spondin
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize RSPO3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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