Rabbit polyclonal RUNX2 antibody (A2851)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RUNX2 antibody (A2851)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:200 – 1:1000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RUNX2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

CCD antibody, AML3 antibody, CCD1 antibody, CLCD antibody, OSF2 antibody, CBFA1 antibody, OSF-2 antibody, PEA2aA antibody, PEBP2aA antibody, CBF-alpha-1 antibody
Acute myeloid leukemia 3 protein antibody|RUNX2 antibody|RUNX2_HUMAN antibody|SL3 3 enhancer factor 1 alpha A subunit antibody|SL3-3 enhancer factor 1 alpha A subunit antibody|SL3/AKV core binding factor alpha A subunit antibody|SL3/AKV core-binding factor alpha A subunit antibody|Anti-RUNX2 antibody (ab76956)

SCBT cat No: sc-101145|sc-390715|sc-8566|sc-390351|sc-10758|sc-12488|

Name

Rabbit polyclonal RUNX2 antibody

Catalogue No.

A2851

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human RUNX2

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:200 – 1:1000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 57kDa/Observed: Refer to Figures

Formulation

RUNX2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RUNX2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CCD antibody, AML3 antibody, CCD1 antibody, CLCD antibody, OSF2 antibody, CBFA1 antibody, OSF-2 antibody, PEA2aA antibody, PEBP2aA antibody, CBF-alpha-1 antibody

Database links

Human UniProt/Swiss-Prot:Q13950

Protein names

CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1

Protein function

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5′-PYGPYGGT-3′, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.

Protein tissue specificity

Specifically expressed in osteoblasts.

Protein sequence and domain

A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and contains the phosphorylation sites.Contains 1 Runt domain.

Protein post-translational modifications

Phosphorylated; probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation (By similarity). Phosphorylation at Ser-451 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression. Isoform 3 is phosphorylated on Ser-340.

Protein cellular localization

Nucleus.

Background

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Research area

All research areas>Transcription Regulators>RUNX
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize RUNX2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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