Rabbit polyclonal RUVBL1 antibody (A5723)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RUVBL1 antibody (A5723)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:20 – 1:50

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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RVB1 antibody, TIH1 antibody, ECP54 antibody, TIP49 antibody, INO80H antibody, NMP238 antibody, PONTIN antibody, TIP49A antibody, Pontin52 antibody
49 kDa TATA box binding protein interacting protein antibody|49 kDa TATA box-binding protein-interacting protein antibody|49 kDa TBP interacting protein antibody|49 kDa TBP-interacting protein antibody|54 kDa erythrocyte cytosolic protein antibody|ECP-54 antibody|ECP54 antibody|ERYTHROCYTE CYTOSOLIC PROTEIN, 54-KD antibody|INO80 complex subunit H antibody|NMP 238 antibody|Nuclear matrix protein 238 antibody|Pontin 52 antibody|PONTIN antibody|RuvB like 1 antibody|RuvB-like 1 antibody|RUVB1_HUMAN antibody|RUVBL1 antibody|RVB1 antibody|TAP54 alpha antibody|TAP54-alpha antibody|TIP49 antibody|TIP49a antibody|TIP60 associated protein 54 alpha antibody|TIP60-associated protein 54-alpha antibody|Anti-TIP49A antibody [2943C1a] (ab51500)

SCBT cat No: sc-81360|sc-393905|sc-393854|sc-48798|sc-365339|sc-15259|

Name

Rabbit polyclonal RUVBL1 antibody

Catalogue No.

A5723

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RUVBL1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:20 – 1:50

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 50kDa/Observed: Refer to Figures

Formulation

RUVBL1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RUVBL1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RVB1 antibody, TIH1 antibody, ECP54 antibody, TIP49 antibody, INO80H antibody, NMP238 antibody, PONTIN antibody, TIP49A antibody, Pontin52 antibody

Database links

Human UniProt/Swiss-Prot:Q9Y265

Protein names

RVB1, TIH1, ECP54, TIP49, INO80H, NMP238, PONTIN, TIP49A, Pontin52

Protein function

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3′ to 5′) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome – DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.; Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation.; May be able to bind plasminogen at cell surface and enhance plasminogen activation.

Protein tissue specificity

Ubiquitously expressed with high expression in heart, skeletal muscle and testis.

Protein sequence and domain

Binding to MYC is dependent on a Myc domain essential for oncogenic activity.Belongs to the RuvB family.

Protein cellular localization

Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note: Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells.

Note

AntibodyPlus can customize RUVBL1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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