Rabbit polyclonal S100B antibody (A0676)

$69.00$259.00

Reactivity: Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal S100B antibody (A0676)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal S100B antibody.

Alternative names:

Check alternative names for the antibody

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S100B antibody,NEF antibody,S100 antibody,S100beta antibody
NEF antibody|Protein S100 B antibody|Protein S100-B antibody|S 100 calcium binding protein beta chain antibody|S 100 protein beta chain antibody|S-100 protein beta chain antibody|S-100 protein subunit beta antibody|S100 antibody|S100 calcium binding protein beta (neural) antibody|S100 calcium-binding protein B antibody|S100 protein beta chain antibody|S100B antibody|S100B_HUMAN antibody|S100beta antibody|Anti-S100 beta antibody [EP1576Y] (ab52642)

SCBT cat No: sc-52204|sc-58837|sc-7849|sc-71991|sc-52205|sc-71990|sc-52206|sc-58839|sc-136061|sc-81709|sc-7851|sc-393919|sc-398707|

Name

Rabbit polyclonal S100B antibody

Catalogue No.

A0676

Reactivity

Mouse, Rat

Immunogen

Recombinant protein of human S100B

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 11kDa/Observed: Refer to Figures

Formulation

S100B antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

S100B antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

S100B antibody,NEF antibody,S100 antibody,S100beta antibody

Database links

Human UniProt/Swiss-Prot:P04271

Protein names

S100B,NEF,S100,S100beta

Protein function

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Protein tissue specificity

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Protein sequence and domain

Belongs to the S-100 family.; Contains 2 EF-hand domains.

Protein cellular localization

Cytoplasm . Nucleus .

Background

Despite their relatively small size (8-12 kDa) and uncomplicated architecture, S100 proteins regulate a variety of cellular processes such as cell growth and motility, cell cycle progression, transcription, and differentiation. To date, 25 members have been identified, including S100A1-S100A18, trichohyalin, filaggrin, repetin, S100P, and S100Z, making it the largest group in the EF-hand, calcium-binding protein family. Interestingly, 14 S100 genes are clustered on human chromosome 1q21, a region of genomic instability. Research studies have demonstrated that significant correlation exists between aberrant S100 protein expression and cancer progression. S100 proteins primarily mediate immune responses in various tissue types but are also involved in neuronal development (1-4).Each S100 monomer bears two EF-hand motifs and can bind up to two molecules of calcium (or other divalent cation in some instances). Structural evidence shows that S100 proteins form antiparallel homo- or heterodimers that coordinate binding partner proximity in a calcium-dependent (and sometimes calcium-independent) manner. Although structurally and functionally similar, individual members show restricted tissue distribution, are localized in specific cellular compartments, and display unique protein binding partners, which suggests that each plays a specific role in various signaling pathways. In addition to an intracellular role, some S100 proteins have been shown to act as receptors for extracellular ligands or are secreted and exhibit cytokine-like activities (1-4).S100B is abundantly expressed in astrocytes and is commonly used as an astrocytic marker in studies of the mammalian CNS. S100B is also expressed in immature and mature myelinating oligodendrocytes that are chondroitin sulfate proteoglycan (NG2)-positive (5).

Research area

All research areas>Structural Proteins>S-100
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize S100B antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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