Rabbit polyclonal SAMHD1 antibody (A7794)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal SAMHD1 antibody (A7794)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

DCIP antibody, CHBL2 antibody, HDDC1 antibody, MOP-5 antibody, SBBI88 antibody
CHBL2 antibody|DCIP antibody|Dendritic cell derived IFNG induced protein antibody|Dendritic cell-derived IFNG-induced protein antibody|Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 antibody|dNTPase antibody|HD domain containing 1 antibody|HDDC1 antibody|Mg11 antibody|Monocyte protein 5 antibody|MOP 5 antibody|MOP-5 antibody|MOP5 antibody|OTTHUMP00000030889 antibody|SAM domain and HD domain 1 antibody|SAM domain and HD domain containing protein 1 antibody|SAM domain and HD domain-containing protein 1 antibody|SAMH1_HUMAN antibody|Samhd1 antibody|SBBI88 antibody|Anti-SAMHD1 antibody [1A1] (ab128107)

SCBT cat No: sc-86212|sc-86213|

Name

Rabbit polyclonal SAMHD1 antibody

Catalogue No.

A7794

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human SAMHD1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 72kDa/Observed: Refer to figures

Formulation

SAMHD1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

SAMHD1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DCIP antibody, CHBL2 antibody, HDDC1 antibody, MOP-5 antibody, SBBI88 antibody

Database links

Human UniProt/Swiss-Prot:Q9Y3Z3

Protein names

DCIP, CHBL2, HDDC1, MOP-5, SBBI88

Protein function

Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.

Protein tissue specificity

Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus.

Protein sequence and domain

Belongs to the SAMHD1 family.; Contains 1 HD domain.; Contains 1 SAM (sterile alpha motif) domain.

Protein post-translational modifications

Ubiquitinated and targeted for proteasomal degradation by a DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase with the help of the viral accessory protein Vpx.

Protein cellular localization

Nucleus .

Background

This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.

Research area

All research areas>Additional Gene Products>SAMHD1
(View all antibody categories related to Additional Gene Products)

Note

AntibodyPlus can customize SAMHD1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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