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Rabbit polyclonal SART1 antibody (A8569)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal SART1 antibody.
Check alternative names for the antibodyExpand
Ara 1 antibody|ARA1 antibody|HOMS 1 antibody|HOMS1 antibody|hSART 1 antibody|hSART1 antibody|hSnu 66 antibody|hSnu66 antibody|IgE autoantigen antibody|MGC2038 antibody|SART 1 antibody|SART1 259 antibody|SART1(259) protein antibody|SART1(800) protein antibody|SART1259 antibody|Snu 66 antibody|Snu66 antibody|Squamous cell carcinoma antigen recognised by T cells antibody|Squamous cell carcinoma antigen recognized by T cells 1 antibody|U4/U6.U5 tri snRNP associated 110 kDa protein antibody|U4/U6.U5 tri snRNP associated protein 1 antibody|Anti-SART1 antibody [EPR14563(B)] (ab181867)
SCBT cat No: sc-376460|sc-376307|sc-376288|sc-292462|
Rabbit polyclonal SART1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human SART1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 90kDa/Observed: Refer to figures
SART1 antibody was tube-contained.
SART1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the SNU66/SART1 family.
|Protein post-translational modifications|| |
Sumoylated with SUMO2.
|Protein cellular localization|| |
Nucleus . Note: Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
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|Product type|| |
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