Rabbit polyclonal SAV1 antibody (A9980)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal SAV1 antibody (A9980)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:4000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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SAV antibody, WW45 antibody, WWP4 antibody
1700040G09Rik antibody|45 kDa WW domain protein antibody|hWW 45 antibody|hWW45 antibody|Protein salvador homolog 1 antibody|salvador family WW domain containing protein 1 antibody|salvador homolog 1 (Drosophila) antibody|Salvador homolog 1 antibody|Salvador, Drosophila, homolog of antibody|SAV 1 antibody|SAV antibody|SAV1 antibody|SAV1_HUMAN antibody|WW 45 antibody|WW domain containing antibody|WW domain-containing adaptor 45 antibody|WW domain-containing protein, 45-KD antibody|WW45 antibody|WW45 protein antibody|WWP 4 antibody|WWP4 antibody|Anti-SAV1 antibody (ab105105)

SCBT cat No: sc-374366|sc-135394|sc-101205|

Name

Rabbit polyclonal SAV1 antibody

Catalogue No.

A9980

Reactivity

Human

Immunogen

Recombinant protein of human SAV1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:1000 – 1:4000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to Figures

Formulation

SAV1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

SAV1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SAV antibody, WW45 antibody, WWP4 antibody

Database links

Human UniProt/Swiss-Prot:Q9H4B6

Protein names

SAV, WW45, WWP4

Protein function

Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

Protein tissue specificity

Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines.

Protein sequence and domain

Contains 1 SARAH domain.; Contains 2 WW domains.

Protein post-translational modifications

Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule.

Protein cellular localization

Nucleus . Cytoplasm .

Background

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

Note

AntibodyPlus can customize SAV1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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