Rabbit polyclonal SDCBP antibody (A5360)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal SDCBP antibody (A5360)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ST1 antibody, SYCL antibody, MDA-9 antibody, TACIP18 antibody
MDA-9 antibody|MDA9 antibody|Melanoma differentiation-associated protein 9 antibody|Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody|Scaffold protein Pbp1 antibody|SDCB1_HUMAN antibody|SDCBP antibody|ST1 antibody|SYCL antibody|Syndecan binding protein (syntenin) antibody|Syndecan binding protein 1 antibody|Syndecan-binding protein 1 antibody|Syntenin 1 antibody|Syntenin-1 antibody|TACIP18 antibody|Anti-Syntenin antibody [EPR8102] (ab133267)

SCBT cat No:

Name

Rabbit polyclonal SDCBP antibody

Catalogue No.

A5360

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human SDCBP

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 32kDa/Observed: Refer to Figures

Formulation

SDCBP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

SDCBP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ST1 antibody, SYCL antibody, MDA-9 antibody, TACIP18 antibody

Database links

Human UniProt/Swiss-Prot:O00560

Protein names

ST1, SYCL, MDA-9, TACIP18

Protein function

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis . Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 . In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis . Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types . In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) . May also play a role in vesicular trafficking . Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway .

Protein tissue specificity

Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) . Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.

Protein sequence and domain

Contains 2 PDZ (DHR) domains.

Protein post-translational modifications

Phosphorylated on tyrosine residues.

Protein cellular localization

Cell junction, focal adhesion . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus . Melanosome . Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Secreted, exosome . Membrane raft . Note: Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Background

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research area

All research areas>Neurobiology>syntenin
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize SDCBP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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