Rabbit Polyclonal SEPT4 antibody (A10238)

$99.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal SEPT4 antibody (A10238)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:200 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

H5 antibody; ARTS antibody; MART antibody; SEP4 antibody; CE5B3 antibody; PNUTL2 antibody; hucep-7 antibody; BRADEION antibody; hCDCREL-2 antibody;
Cerebral protein 7 antibody|H5 antibody|hCDCREL-2 antibody|hucep-7 antibody|MART antibody|Peanut-like protein 2 antibody|PNUTL2 antibody|SEP 4 antibody|SEP4 antibody|Sept4 antibody|SEPT4_HUMAN antibody|Septin M antibody|Septin-4 antibody|Anti-SEPT4 antibody (ab166788)

SCBT cat No:

Name

Rabbit Polyclonal SEPT4 antibody

Catalogue No.

A10238

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human SEPT4

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

55kDa

Formulation

SEPT4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

H5 antibody; ARTS antibody; MART antibody; SEP4 antibody; CE5B3 antibody; PNUTL2 antibody; hucep-7 antibody; BRADEION antibody; hCDCREL-2 antibody;

Protein names

H5; ARTS; MART; SEP4; CE5B3; PNUTL2; hucep-7; BRADEION; hCDCREL-2;

Protein function

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.

Protein tissue specificity

Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets.

Protein sequence and domain

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.; Contains 1 septin-type G (guanine nucleotide-binding) domain.

Protein cellular localization

Cytoplasm . Cytoplasm, cytoskeleton . Note=In platelets, found in areas surrounding alpha-granules.; Isoform ARTS: Mitochondrion. Nucleus. Note=While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction.

Background

This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.

Note

AntibodyPlus can customize SEPT4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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