Rabbit Polyclonal SIRPA antibody (A9001)

$99.00$259.00

Reactivity: Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal SIRPA antibody (A9001)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:200 – 1:2000

Recommended protocols: check protocols

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Alternative names:

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Signal regulatory protein alpha type 1 antibody|Bit antibody|Brain Ig like molecule with tyrosine based activation motifs antibody|Brain Ig-like molecule with tyrosine-based activation motifs antibody|Brain immunoglobulin like molecule with tyrosine based activation motifs antibody|CD172 antigen like family member A antibody|CD172 antigen-like family member A antibody|CD172a antibody|CD172a antigen antibody|Inhibitory receptor SHPS-1 antibody|Macrophage fusion receptor antibody|MFR antibody|MYD 1 antibody|Myd 1 antigen antibody|MyD-1 antigen antibody|p84 antibody|Protein tyrosine phosphatase non receptor type substrate 1 antibody|PTPNS1 antibody|SHP substrate 1 antibody|SHPS-1 antibody|SHPS1 antibody|SHPS1_HUMAN antibody|Signal regulatory protein alpha 2 antibody|Signal regulatory protein alpha 3 antibody|Signal regulatory protein alpha antibody|Signal regulatory protein alpha type 2 antibody|Signal-regulatory protein alpha-1 antibody|Signal-regulatory protein alpha-2 antibody|Signal-regulatory protein alpha-3 antibody|SIRP antibody|Sirp-alpha-1 antibody|Sirp-alpha-2 antibody|Sirp-alpha-3 antibody|SIRPA antibody|SIRPalpha antibody|SIRPalpha1 antibody|SIRPalpha2 antibody|SIRPalpha3 antibody|Tyrosine phosphatase SHP substrate 1 antibody|Tyrosine protein phosphatase non receptor type substrate 1 antibody|Tyrosine-protein phosphatase non-receptor type substrate 1 antibody|Anti-SIRP alpha antibody (ab53721)

SCBT cat No:

Name

Rabbit Polyclonal SIRPA antibody

Catalogue No.

A9001

Reactivity

Mouse, Rat

Immunogen

Recombinant protein of human SIRPA

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

55kDa

Formulation

SIRPA antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Protein function

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Protein tissue specificity

Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

Protein sequence and domain

Contains 2 Ig-like C1-type (immunoglobulin-like) domains.; Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Protein post-translational modifications

N-glycosylated.; Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.

Protein cellular localization

Membrane; Single-pass type I membrane protein.

Background

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

Note

AntibodyPlus can customize SIRPA antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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