Rabbit Polyclonal SLC11A2 antibody (A10231)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal SLC11A2 antibody (A10231)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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DCT1 antibody; DMT1 antibody; AHMIO1 antibody; NRAMP2 antibody;
DCT 1 antibody|dct-1 antibody|DCT1 antibody|Divalent cation transporter 1 antibody|Divalent metal transporter 1 antibody|DMT 1 antibody|DMT-1 antibody|DMT1 antibody|FLJ37416 antibody|Natural resistance associated macrophage protein 2 antibody|Natural resistance-associated macrophage protein 2 antibody|NRAM2_HUMAN antibody|NRAMP 2 antibody|NRAMP2 antibody|OK/SW-cl.20 antibody|Slc11a2 antibody|Solute carrier family 11 (proton coupled divalent metal ion transporters) member 2 antibody|Solute carrier family 11 member 2 antibody|Anti-DMT1 antibody (ab55735)

SCBT cat No: sc-166884|sc-30120|sc-16887|sc-30926|

Name

Rabbit Polyclonal SLC11A2 antibody

Catalogue No.

A10231

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human SLC11A2

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

62kDa

Formulation

SLC11A2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DCT1 antibody; DMT1 antibody; AHMIO1 antibody; NRAMP2 antibody;

Protein names

DCT1; DMT1; AHMIO1; NRAMP2;

Protein function

Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.

Protein tissue specificity

Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney.

Protein sequence and domain

Belongs to the NRAMP family.

Protein post-translational modifications

Ubiquitinated by WWP2.; N-glycosylated.

Protein cellular localization

Isoform 2: Cell membrane ; Multi-pass membrane protein . Early endosome .; Endosome membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein .

Background

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize SLC11A2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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