Rabbit Polyclonal SNCB antibody (A10443)

$99.00$259.00

Reactivity: Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal SNCB antibody (A10443)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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14 kDa brain-specific protein antibody|Beta-synuclein antibody|Phosphoneuroprotein 14 antibody|PNP14 antibody|Sncb antibody|Synuclein beta antibody|SYUB_HUMAN antibody|Anti-beta Synuclein antibody [EP1537Y] (ab76111)

SCBT cat No: sc-136452|sc-9565|sc-9564|

Name

Rabbit Polyclonal SNCB antibody

Catalogue No.

A10443

Reactivity

Mouse, Rat

Immunogen

Recombinant protein of human SNCB

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

15kDa

Formulation

SNCB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Protein function

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Protein tissue specificity

Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

Protein sequence and domain

Belongs to the synuclein family.

Protein post-translational modifications

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.

Protein cellular localization

Cytoplasm.

Background

This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Neurobiology/">Neurobiology</a>><a href="http://antibodyplus.com/product-tag/synuclein/">synuclein</a><br><a href="http://antibodyplus.com/product-tag/Neurobiology/"&gt; (View all antibody categories related to Neurobiology)</a>

Note

AntibodyPlus can customize SNCB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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