No products in the cart.
Rabbit Polyclonal TNPO1 antibody (A9435)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:200 – 1:1000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal TNPO1 antibody.
Check alternative names for the antibodyExpand
Importin 2 antibody|Importin beta 2 antibody|Importin beta-2 antibody|IPO 2 antibody|IPO2 antibody|Karyopherin (importin) beta 2 antibody|Karyopherin beta 2 antibody|Karyopherin beta-2 antibody|KPN B2 antibody|KPNB 2 antibody|KPNB2 antibody|M9 interacting protein antibody|M9 region interacting protein antibody|M9 region interaction protein antibody|MIP 1 antibody|MIP antibody|MIP1 antibody|OTTHUMP00000126960 antibody|OTTHUMP00000222024 antibody|OTTHUMP00000226224 antibody|TNPO 1 antibody|Tnpo1 antibody|TNPO1_HUMAN antibody|Transportin 1 antibody|Transportin antibody|Transportin-1 antibody|Transportin1 antibody|TRN antibody|Anti-Transportin 1 antibody [D45] (ab10303)
SCBT cat No: sc-32314|sc-166127|sc-11368|sc-101539|sc-365179|sc-6914|
Rabbit Polyclonal TNPO1 antibody
|Catalogue No.|| |
A synthetic peptide of human TNPO1
|Recommended dilution|| |
WB 1:200 – 1:1000
|Molecular weight|| |
TNPO1 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/Q92973">Q92973</a>
|Protein function|| |
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.
|Protein sequence and domain|| |
Belongs to the importin beta family. Importin beta-2 subfamily.; Contains 20 HEAT repeats.; Contains 1 importin N-terminal domain.
|Protein cellular localization|| |
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]
AntibodyPlus can customize TNPO1 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
There are no reviews for this product yet.
By submitting a review, get following benefits:
1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!
There is no extra validation for this product yet.
Check other extra validated antibodies below: