Rabbit Polyclonal TNPO1 antibody (A9435)

$99.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal TNPO1 antibody (A9435)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:200 – 1:1000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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Importin 2 antibody|Importin beta 2 antibody|Importin beta-2 antibody|IPO 2 antibody|IPO2 antibody|Karyopherin (importin) beta 2 antibody|Karyopherin beta 2 antibody|Karyopherin beta-2 antibody|KPN B2 antibody|KPNB 2 antibody|KPNB2 antibody|M9 interacting protein antibody|M9 region interacting protein antibody|M9 region interaction protein antibody|MIP 1 antibody|MIP antibody|MIP1 antibody|OTTHUMP00000126960 antibody|OTTHUMP00000222024 antibody|OTTHUMP00000226224 antibody|TNPO 1 antibody|Tnpo1 antibody|TNPO1_HUMAN antibody|Transportin 1 antibody|Transportin antibody|Transportin-1 antibody|Transportin1 antibody|TRN antibody|Anti-Transportin 1 antibody [D45] (ab10303)

SCBT cat No: sc-32314|sc-166127|sc-11368|sc-101539|sc-365179|sc-6914|

Name

Rabbit Polyclonal TNPO1 antibody

Catalogue No.

A9435

Reactivity

Human, Mouse

Immunogen

A synthetic peptide of human TNPO1

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

102kDa

Formulation

TNPO1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Protein function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.

Protein sequence and domain

Belongs to the importin beta family. Importin beta-2 subfamily.; Contains 20 HEAT repeats.; Contains 1 importin N-terminal domain.

Protein cellular localization

Cytoplasm. Nucleus.

Background

This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]

Note

AntibodyPlus can customize TNPO1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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