Rabbit Polyclonal UBQLN2 antibody (A9568)

$99.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal UBQLN2 antibody (A9568)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:200 – 1:2000
IHC 1:20 – 1:200
IF 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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bA431N15.1 antibody|CHAP 1 antibody|CHAP1 antibody|CHAP1/DSK2 antibody|Dsk 2 antibody|Dsk2 antibody|DSK2 homolog antibody|hPLIC 2 antibody|hPLIC2 antibody|HRIHFB2157 antibody|LIC 2 antibody|LIC2 antibody|N4BP4 antibody|Nedd4 binding protein 4 antibody|PLIC 2 antibody|PLIC2 antibody|Protein linking IAP with cytoskeleton 2 antibody|RIHFB2157 antibody|Ubiquilin 2 antibody|Ubiquilin2 antibody|Ubiquitin like product Chap1/Dsk2 antibody|UBQLN 2 antibody|Anti-UBQLN2 antibody [6H9] (ab190283)

SCBT cat No: sc-14658|sc-100612|

Name

Rabbit Polyclonal UBQLN2 antibody

Catalogue No.

A9568

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human UBQLN2

Host

Rabbit

Applications

WB, IHC, IF

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

66kDa

Formulation

UBQLN2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Protein function

Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).

Protein sequence and domain

Contains 4 STI1 domains.; Contains 1 UBA domain.; Contains 1 ubiquitin-like domain. The ubiquitin-like domain is essential for its inhibitory effect on GPCR endocytosis. Mediates its association with the subunits of the proteasome.; The UBA domain is essential for its association with microtubule-associated protein 1 light chain 3 (MAP1LC3). Mediates its association with ubiquitinated substrates.; Dimerization is dependent upon the central region of the protein containing the STI1 domains and is independent of its ubiquitin-like and UBA domains.

Protein post-translational modifications

Degraded during macroautophagy.

Protein cellular localization

Cytoplasm . Nucleus . Membrane . Cytoplasmic vesicle, autophagosome . Note=Colocalizes with a subset of proteasomes, namely those that are cytoskeleton associated or free in the cytosol. Associated with fibers in mitotic cells.

Background

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]

Note

AntibodyPlus can customize UBQLN2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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