Rabbit Polyclonal ULK2 antibody (STJ98597)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal ULK2 antibody (STJ98597)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

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ULK2 antibody, KIAA0623 antibody,|ATG1B antibody|KIAA0623 antibody|Serine/threonine protein kinase ULK2 antibody|Serine/threonine-protein kinase ULK2 antibody|ULK2 antibody|ULK2_HUMAN antibody|Unc 51 (C. elegans) like kinase 2 antibody|Unc 51 like autophagy activating kinase 2 antibody|Unc 51 like kinase 2 antibody|Unc-51-like kinase 2 antibody|Unc51.2 antibody|Anti-ULK2 antibody (ab97695)
SCBT cat No: To be updated

 

Name

ULK2 Polyclonal Antibody

Catalogue No.

STJ98597

Reactivity

Human, Mouse, Rat

Specificity

ULK2 Polyclonal Antibody detects endogenous levels of ULK2

Immunogen

Synthetic Peptide of ULK2

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Formulation

ULK2 Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

ULK2 Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Serine/threonine-protein kinase ULK2 antibody, Unc-51-like kinase 2 antibody

Database links

Human UniProt/Swiss-Prot:Q8IYT8;Mouse UniPort/Swiss-Prot: Q9QY01;Rat UniProt/Swiss-Port: D3Z9J7;Human Entrez Gene: 9706;Mouse Entrez Gene: 29869;Rat Entrez Gene: Rn.17602

Protein names

Serine/threonine-protein kinase ULK2 , Unc-51-like kinase 2

Protein function

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. / ATP + a protein = ADP + a phosphoprotein.

Protein sequence and domain

The CTD-like region mediates membrane-binding and incorporation into large protein complexes. / Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. / Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy.

Protein cellular localization

Cytoplasmic vesicle membrane / Peripheral membrane protein

Research area

All research areas>Kinases and Phosphatases>ULK2
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize ULK2 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


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Antibody customer reviews & validation data - 31

Validation data ID: 31

Submission date: 2016-12-07

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Figure description:

Labeling is very clear

Product name

Anti-Beclin1, Anti-ULK1, Anti-ATG9A, Anti-AMBRA1

Product catalog No.

STJ98594,STJ98597,STJ98589,STJ98593

Product type

Primary antibody

Supplier

St John's Laboratory Ltd

Application type

Western Blot

Antibody specificity rating

Average

Antibody overall rating

Fair

Your comments

I had to wash my membranes for 2 hours after secondary antibody. It takes so much to get rid of impurities.

Detailed protocol

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