Rabbit Polyclonal USP13 antibody (A10264)

$99.00$259.00

Reactivity: Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal USP13 antibody (A10264)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ISOT3 antibody; IsoT-3 antibody;
Deubiquitinating enzyme 13 antibody|Isopeptidase T 3 antibody|Isopeptidase T-3 antibody|Isopeptidase T3 antibody|ISOT 3 antibody|ISOT-3 antibody|ISOT3 antibody|Ubiquitin carboxyl terminal hydrolase 13 antibody|Ubiquitin carboxyl-terminal hydrolase 13 antibody|Ubiquitin specific peptidase 13 (isopeptidase T3) antibody|Ubiquitin specific peptidase 13 antibody|Ubiquitin specific processing protease 13 antibody|Ubiquitin specific protease 13 antibody|Ubiquitin thioesterase 13 antibody|Ubiquitin thiolesterase 13 antibody|Ubiquitin-specific-processing protease 13 antibody|UBP13 antibody|UBP13_HUMAN antibody|USP 13 antibody|USP13 antibody|Anti-USP13 antibody [EPR4348] (ab109264)

SCBT cat No:

Name

Rabbit Polyclonal USP13 antibody

Catalogue No.

A10264

Reactivity

Mouse, Rat

Immunogen

Recombinant protein of human USP13

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

97kDa

Formulation

USP13 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ISOT3 antibody; IsoT-3 antibody;

Protein names

ISOT3; IsoT-3;

Protein function

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.

Protein tissue specificity

Highly expressed in ovary and testes.

Protein sequence and domain

Belongs to the peptidase C19 family.; Contains 2 UBA domains.; Contains 1 UBP-type zinc finger.; Contains 1 USP domain. The UBP-type zinc finger has lost its ability to bind ubiquitin and USP13 is not activated by unanchored ubiquitin. Swapping with the UBP-type zinc finger from USP5 restores ability to bind unanchored ubiquitin and subsequent activation of the protein (PubMed:22216260).; The UBA domains mediate binding to ubiquitin.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Synthesis-and-Degradation/">Synthesis and Degradation</a>><a href="http://antibodyplus.com/product-tag/USP13/">USP13</a><br><a href="http://antibodyplus.com/product-tag/Synthesis-and-Degradation/"&gt; (View all antibody categories related to Synthesis and Degradation)</a>

Note

AntibodyPlus can customize USP13 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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