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High-mobility group box 1 (HMGB1) is a conserved nucleoprotein that plays an important role in maintaining nucleosomal stability, DNA recombination, replication, repair and transcription. Which can be released by necrotic cells, or in the appropriate stimulation of the active secretion to the extracellular. Recent studies have shown that activation of HMGB1 signal is closely related to the development of lung diseases such as lung injury, pulmonary fibrosis and lung cancer, and blockade of HMGB1 signal can inhibit its pathological progression, indicating that HMGB1 has a potential therapeutic value for these diseases The This paper reviews the role of HMGB1 in respiratory diseases and its mechanism in order to provide a new theoretical basis for the diagnosis and treatment of these diseases.
Role and mechanisms of HMGB1 in respiratory diseases
Article in Chinese Pharmacological Bulletin 31(1):15-18 · January 2015
Also published on Medium.