The findings suggest that during hypoxia HMGB1 upregulates mitochondrial biogenesis in HCC cancer cells promoting tumor survival and proliferation.
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HMGB1 participates in organ damage and immune rejection after transplantation and may become a marker for successful organ implantation.
Leave a comment | HMGB1 associated molecular patterns (DAMP) has been shown to be involved in the development of multiple organ IRIs.
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This provides a new idea for elucidating the pathogenesis of RA and provides a new target for the treatment of RA.
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HMGB1 is thought to be a key late proinflammatory mediator of sepsis.
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A protein-sugar molecule, CD99, occurs more frequently than normal on stem cells responsible for blood cancers, including acute myeloid leukemia (AML) and the...
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A team at the Wellcome Trust Sanger Institute has discovered how a promising malarial vaccine target - the protein RH5 - helps parasites...
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As an arm of the innate immune system, white blood cells called neutrophils form the first line of defense against invading pathogens. Neutrophils...
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For most vaccines to work the body needs two cell types - B cells and T helper cells - to make antibodies. B...
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Scientists propose in Nature blocking a molecule that drives inflammation and organ damage in Gaucher and maybe other lysosomal storage diseases as a...
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The delivery of chemical messenger (neurotransmitter) receptors to the junctions between nerve cells (synapses) is crucial to cognitive processes such as memory. One...
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A University of Cincinnati (UC) researcher who has developed an immunotherapy to help reverse cocaine addiction that's been successful in animal models says...
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